A comprehensive screening checklist covering FIT-DNA, trace elements, reproductive hormones and specialty testing.

Health checkup E: tests and optional items

Review the checklist, which includes FIT-DNA. Capsule endoscopy, TWIST1 and BRCA testing are optional; a clinician must assess suitability and the hospital must confirm any separate charges.

Test selection depends on age, symptoms, medical history and family history. Tumor markers alone cannot diagnose or exclude cancer; a panel should not be treated as universal cancer screening.

Screening information · NCI ↗FIT-DNA · NCI ↗
  • Physical exams, laboratory markers, imaging, ultrasound and functional tests
  • Ophthalmology category C, CA153, BNP, EB antibody and seven trace elements
  • Lumbar film, reproductive hormones and multi-target stool FIT-DNA
  • Optional FSH/LH, capsule endoscopy, Twist1 and BRCA1/2

Package contents

01

Baseline exam and routine checks

Baseline physical, routine and general screening items.

Physician physical examination

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General measurements: height, weight, waist-to-hip ratio. Internal medicine: heart, lungs, liver, spleen, and related systems. Surgery: breasts, thyroid, digital rectal examination, etc. Ophthalmology: visual acuity, color vision. ENT: external auditory canals, nose, pharynx, etc. Dentistry: oral health status and treatment planning overview.
Clinical value
The most direct and fundamental assessment of overall physical status.
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Routine laboratory

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*Complete blood count (CBC) + high-sensitivity C-reactive protein (hs-CRP); urinalysis
Clinical value
Screens for hematologic disorders, infectious disease, urinary tract infection and renal disease.
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Urinary microalbumin quantification (random urine)

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Urinary microalbumin quantification (random urine)
Clinical value
A sensitive indicator of glomerular disease and renal tubular injury.
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Creatinine (random urine)

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Creatinine (random urine)
Clinical value
Evaluates kidney function and reflects muscle metabolism.
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Stool routine examination + fecal occult blood

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Stool routine examination + fecal occult blood
Clinical value
Screens for gastrointestinal infection and lesions.
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*Erythrocyte sedimentation rate (ESR)

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Erythrocyte sedimentation rate (ESR)
Clinical value
Helps screen for hematologic, tuberculosis-related, rheumatologic, oncologic and immune-mediated disorders.
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02

Blood, biochemistry, immune and metabolic markers

Coverage across metabolic, immune, tumor, reproductive hormone and specialty markers.

*Comprehensive biochemistry panel

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Comprehensive biochemical profile
Clinical value
Assesses liver function, kidney function, blood glucose, blood lipids, proteins, uric acid, electrolytes and overall systemic metabolism.
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α-L-Fucosidase (AFU)

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α-L-Fucosidase (AFU) assay
Clinical value
A clinician may interpret this alongside other tests in specific diagnostic or monitoring settings. It cannot diagnose or exclude cancer on its own and is not routine cancer screening for everyone without symptoms.
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*Homocysteine

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Homocysteine
Clinical value
Helps predict risk of cardiovascular events and stroke.
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*Small dense low-density lipoprotein (sdLDL)

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Small dense low-density lipoprotein (sdLDL)
Clinical value
Assists cardiovascular risk stratification.
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*Glycated hemoglobin (HbA1c)

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Glycated hemoglobin (HbA1c)
Clinical value
Reflects average blood glucose control over approximately the past 2–3 months; supports diabetes monitoring.
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*Glycated albumin (GA)

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Glycated albumin (GA)
Clinical value
Reflects glycemic control over approximately the past 2–4 weeks; useful for short-term glucose assessment.
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*Free fatty acids

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Free fatty acids
Clinical value
Evaluates lipid metabolism.
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*Cystatin C

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Cystatin C
Clinical value
Assesses renal function.
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*Insulin

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Fasting insulin
Clinical value
Evaluates pancreatic beta-cell insulin secretion.
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*Vitamin B12

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Vitamin B12
Clinical value
Screens for megaloblastic anemia; participates in homocysteine metabolism and aids cardiovascular risk factor assessment.
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*Folate

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Folate
Clinical value
Screens cardiovascular risk factors and evaluates nutritional status.
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*Cortisol

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Cortisol
Clinical value
Screens disorders such as exogenous/simple obesity-related patterns, adrenal hyperplasia and hypercortisolism.
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*Thyroid function panel (seven tests)

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FT3, FT4, TT3, TT4, anti-TG, anti-TPO, TSH
Clinical value
Evaluates thyroid function.
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*Serum iron

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Serum iron
Clinical value
Screens iron deficiency states and anemia.
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*25-Hydroxyvitamin D [25(OH)D]

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25-Hydroxyvitamin D
Clinical value
Supports evaluation of bone and mineral metabolism.
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*Parathyroid hormone (PTH)

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Parathyroid hormone (PTH)
Clinical value
Primarily used to assess parathyroid function.
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*Apolipoproteins

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ApoA, ApoB
Clinical value
Assesses apolipoprotein levels and lipid transport.
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*Creatine kinase-MB isoenzyme (CK-MB)

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Creatine kinase-MB isoenzyme (CK-MB)
Clinical value
Screens myocarditis, myocardial infarction and other cardiac conditions.
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*Serum protein electrophoresis

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Serum protein electrophoresis
Clinical value
Helps screen for hematologic, rheumatologic, oncologic and immune-related disorders.
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*Oxidized low-density lipoprotein (OxLDL)

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Oxidized low-density lipoprotein cholesterol
Clinical value
Supports prevention, monitoring and early diagnosis of cardiovascular disease and lipid metabolism disorders.
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*Apolipoprotein E (apoE)

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Apolipoprotein E (apoE)
Clinical value
Associated with dyslipidemia, Alzheimer disease, atherosclerosis, coronary artery disease, Parkinson disease and stroke.
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*Human epididymis protein 4 (HE4)

Applicability: Female only
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Human epididymis protein 4 (HE4)
Clinical value
A clinician may interpret this alongside other tests in specific diagnostic or monitoring settings. It cannot diagnose or exclude cancer on its own and is not routine cancer screening for everyone without symptoms.
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*Expanded tumor markers (add-on)

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CA125, NSE
Clinical value
A clinician may interpret this alongside other tests in specific diagnostic or monitoring settings. It cannot diagnose or exclude cancer on its own and is not routine cancer screening for everyone without symptoms.
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*Thyrotropin receptor antibodies (TRAb)

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Thyrotropin receptor antibody assay
Clinical value
Important ancillary test for Graves disease and autoimmune thyroid disorders.
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*Hepatic fibrosis panel (four biomarkers)

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Hepatic fibrosis four-marker panel
Clinical value
Supports diagnosis and staging of hepatic fibrosis.
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*Bone turnover markers (three tests)

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Osteocalcin, β–cross-linked C-telopeptide of type I collagen (β-CTX), total procollagen type I N-terminal propeptide (Total-P1NP)
Clinical value
Integrated evaluation of metabolic bone disease, bone turnover and systemic disorders affecting bone.
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N-acetyl-β-D-glucosaminidase (NAG)

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Urinary NAG
Clinical value
Elevated urinary NAG is an early sign of renal injury and a sensitive marker of tubular damage.
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α1-Microglobulin (α1-MG)

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Urinary α1-microglobulin (α1-MG)
Clinical value
Early marker of proximal tubular dysfunction.
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*Coagulation panel (four tests)

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PT, APTT, fibrinogen, TT
Clinical value
Evaluates intrinsic and extrinsic coagulation pathways.
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*Allergen-specific IgE panel

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Screening IgE antibodies to fourteen allergens
Clinical value
Identifies atopic sensitization patterns.
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*Rheumatoid and inflammatory arthritis serology

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ASO, CRP, rheumatoid factor (RF)
Clinical value
Supports rheumatic disease diagnosis and monitors inflammatory activity.
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*Thrombelastography (TEG)—standard assay

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Thrombelastography, routine assay
Clinical value
Global assessment of clot formation and dissolution; stratifies thrombotic versus bleeding tendencies.
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*Expanded tumor markers (add-on)

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CA72-4
Clinical value
A clinician may interpret this alongside other tests in specific diagnostic or monitoring settings. It cannot diagnose or exclude cancer on its own and is not routine cancer screening for everyone without symptoms.
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*Ceruloplasmin

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Ceruloplasmin (CER)
Clinical value
Aids evaluation of inflammatory, hepatic, renal and malignant conditions.
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*T lymphocyte subsets / immunophenotype

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T-cell, NK-cell and related immune subsets
Clinical value
Assesses cellular immunity relevant to autoimmune and infectious disorders.
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*Secondary hypertension biomarker panel (four hormones)

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Renin-angiotensin-aldosterone axis–related assays (clinic-standard four-test panel)
Clinical value
Helps differentiate secondary causes of hypertension.
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*Apolipoprotein A-II (apoA-II)

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Apolipoprotein A-II (apoA-II)
Clinical value
Correlates with cardiovascular and oncology risk pathways.
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*Tumor marker add-on—CA15-3

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Carbohydrate antigen 15-3 (CA15-3)
Clinical value
A clinician may interpret this alongside other tests in specific diagnostic or monitoring settings. It cannot diagnose or exclude cancer on its own and is not routine cancer screening for everyone without symptoms.
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*B-type natriuretic peptide (BNP)

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B-type natriuretic peptide (BNP)
Clinical value
Biochemical support for diagnosing and stratifying heart failure.
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*Epstein-Barr virus (EBV) serology

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EBV antibody profile
Clinical value
Evaluates latent EBV infection and supports nasopharyngeal carcinoma risk assessment.
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*Trace elements and toxic metals panel (seven tests)

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Serum: copper, zinc, magnesium; urine: lead, mercury, arsenic
Clinical value
Screens essential trace-element balance and toxic heavy-metal exposure markers.
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*Reproductive hormone panel

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Male: prolactin (PRL), testosterone (T), estradiol (E2), FSH, LH; female: prolactin (PRL), progesterone (P), testosterone (T), estradiol (E2)
Clinical value
Evaluates pituitary-ovarian (or pituitary-testicular) axis function.
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Multitarget fecal FIT-DNA assay

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Stool DNA and fecal immunochemical testing.
Clinical value
May be a colorectal screening option for eligible people. A positive result requires follow-up colonoscopy; a clinician determines suitability.
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Disposable supplies

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Vacuum blood collection tubes
Clinical value
Standard phlebotomy consumables.
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03

Imaging, ultrasound and functional tests

Includes ophthalmology, spine imaging, ultrasound and functional tests.

Electrocardiogram (ECG)

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Computerized 12-lead electrocardiogram
Clinical value
Assists diagnosis of cardiac disease.
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Chest posteroanterior radiograph—digital DR (no films)

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Digital radiography chest posteroanterior view (ribs not included)
Clinical value
Assesses pulmonary parenchyma and major thoracic structures.
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*Color Doppler ultrasound: liver, gallbladder, spleen and pancreas

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Liver, gallbladder, spleen, pancreas
Clinical value
Evaluates abdominal organ anatomy and pathology.
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Thyroid color Doppler ultrasound

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Thyroid color Doppler ultrasound
Clinical value
Screens thyroid disease.
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Male urinary tract color Doppler ultrasound (full bladder required)

Applicability: Male only
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Color Doppler ultrasound of both kidneys, ureters, urinary bladder and prostate
Clinical value
Evaluates anatomy and pathology of the kidneys, ureters, bladder and prostate.
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Breast color Doppler ultrasound

Applicability: Female only
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Breast color Doppler ultrasound
Clinical value
Screens benign and malignant breast conditions.
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Bone densitometry

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Quantitative ultrasound bone densitometry
Clinical value
Assesses bone mineral status and screens for osteoporosis and bone loss.
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Body metabolism dynamic composition analysis ×2

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Body metabolism dynamic composition analysis
Clinical value
Dynamic screening for visceral adiposity patterns and cardiometabolic risk, with osteoporosis risk context.
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*Urea breath test—¹³C (H. pylori)

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Helicobacter pylori testing (urea breath)
Clinical value
Screens active H. pylori infection.
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Pulmonary function testing

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Spirometry and ventilatory function assessment
Clinical value
Characterizes baseline lung mechanics and airflow.
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Fundus photography

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Color fundus photography
Clinical value
Screens retinal, macular, optic disc and retinal vascular disease.
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Arterial stiffness assessment

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Pulse wave velocity / arterial elasticity testing
Clinical value
Non-invasive assessment of vascular stiffness and systemic atherosclerotic burden.
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Carotid artery color Doppler ultrasound

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Bilateral carotid color Doppler ultrasound
Clinical value
Assesses carotid atherosclerosis and supports coronary artery disease risk stratification.
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Transthoracic echocardiography

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Color Doppler echocardiography
Clinical value
Evaluates cardiac structure and function.
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***Low-dose screening chest CT + AI analysis (no films)

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Low-dose screening chest CT with artificial-intelligence-assisted reading
Clinical value
Detailed lung imaging with AI-augmented nodule detection and characterization.
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Cervical spine AP and lateral radiographs—digital DR (no films)

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Digital radiography cervical spine AP and lateral views
Clinical value
Assesses cervical alignment, vertebrae, discs, foraminal zones and ligament-related changes.
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Ophthalmology package C

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Visual acuity; color vision; slit-lamp anterior segment examination; intraocular pressure
Clinical value
Screens gross visual function, color deficiency, anterior segment pathology, and elevated IOP glaucoma-related risk.
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Lumbar spine AP and lateral radiographs—digital DR (no films)

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Digital radiography lumbar spine AP and lateral views
Clinical value
Assesses lumbar alignment and structural changes.
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04

Gender-specific pathways

Gender-specific and gynecology tests tailored to each pathway.

Gynecologic pelvic ultrasound

Applicability: Female only
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Transabdominal gynecologic color Doppler ultrasound (full bladder) or transvaginal color Doppler ultrasound; uterus, adnexa, ovaries
Clinical value
Evaluates pelvic organ anatomy and pathology.
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**Gynecologic examination

Applicability: Female with sexual history
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Speculum examination and bimanual pelvic examination
Clinical value
Standard gynecologic clinical examination.
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**Immunofluorescence staining with diagnostic interpretation

Applicability: Female with sexual history
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Fluorescent assay of vaginal secretions
Clinical value
Screens for candidiasis, bacterial vaginosis and trichomoniasis.
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**ThinPrep cervical cytology (TCT)

Applicability: Female with sexual history
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Liquid-based thin-layer cervical cytology
Clinical value
Evaluates cervical cell morphology and supports cervical cancer screening.
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**HPV DNA assay (13 high-risk genotypes)

Applicability: Female with sexual history
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Human papillomavirus (HPV) DNA testing
Clinical value
Identifies high-risk HPV infection to support prevention and early management of cervical neoplasia.
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*Tumor marker panel

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CEA, AFP, SCC, PGI, PGII, CA19-9, cytokeratin 19 fragment (Cyfra 21-1), ProGRP, ferritin (Ferritin); males additionally TPSA, FPSA
Clinical value
A clinician may interpret this alongside other tests in specific diagnostic or monitoring settings. It cannot diagnose or exclude cancer on its own and is not routine cancer screening for everyone without symptoms.
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**Candida testing (secretions)

Applicability: Female with sexual history
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Vaginal secretion analysis
Clinical value
Screens for Candida genital tract infection.
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**Gardnerella vaginalis testing (secretions)

Applicability: Female with sexual history
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Vaginal secretion analysis
Clinical value
Screens for Gardnerella vaginalis–associated vaginosis.
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05

Optional tests

Optional upgrades available on request.

*Reproductive hormones—individual test

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Follicle-stimulating hormone (FSH)
Clinical value
Evaluates hypothalamic-pituitary-gonadal axis function (recommended blood draw cycle days 3–5 when applicable).
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*Reproductive hormones—individual test

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Luteinizing hormone (LH)
Clinical value
Evaluates hypothalamic-pituitary-gonadal axis function (recommended blood draw cycle days 3–5 when applicable).
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*Magnetically guided capsule gastroscopy incl. small bowel

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Magnetically controlled capsule endoscopy system (appointment required)
Clinical value
Screens mucosal neoplasia of stomach and small bowel (appointment scheduling required).
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TWIST1 gene methylation assay—department of pathology

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Urinary exfoliated cell TWIST1 promoter methylation testing
Clinical value
Detects aberrant TWIST1 methylation in shed urothelial DNA to aid bladder cancer diagnosis.
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*Germline BRCA1/BRCA2 sequencing—blood sample

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Full coding sequences plus splice sites, promoters and untranslated regions (UTRs) for BRCA1 and BRCA2
Clinical value
Screens hereditary susceptibility to breast, ovarian, prostate and pancreatic malignancies—genetic test; duplication not required elsewhere in the itinerary.
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Notes

Confirm fasting requirements, gynecologic eligibility, and CT guidance when booking.

*Fasting required**Gynecologic items (females with sexual history)***CT imaging (confirm when booking)
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