Visit preparation
My colorectal cancer report says dMMR. Does my family need screening?
Deficient mismatch repair (dMMR) is a tumour test result. Ask whether you need a hereditary risk assessment before deciding what screening your relatives need.
How can the result affect my current treatment?
China’s National Health Commission lists immunotherapy indications for certain patients with MSI-H or dMMR colorectal cancer. Ask whether your test identified missing mismatch repair proteins or high microsatellite instability. Bring the full pathology report and test results so the team can consider them alongside the cancer stage and previous treatment. National Health Commission guidance on anticancer medicines
What do tumour tests and hereditary assessment tell us?
China’s colorectal screening guidance sets out specific recommendations for people at high risk of Lynch syndrome and distinguishes risks associated with different genes. Ask your team what kind of report you already have and whether a separate hereditary assessment is warranted. Chinese colorectal cancer screening guidance
| Information available | What to ask |
|---|---|
| Tumour tissue report showing dMMR or MSI-H | What method was used, is the report complete and how does it affect treatment? |
| Family history or previous hereditary test report | Is genetic counselling appropriate and which relatives need personalised screening? |
Who can advise relatives about when to start screening?
The Chinese screening guidance gives different starting ages for people at high risk of Lynch syndrome depending on the gene involved. Bring a list of relatives with cancer, the sites of those cancers and their ages at diagnosis. Ask whether you should see a genetic counsellor and whether the team can give you a written opinion to share with your clinician at home. Chinese colorectal cancer screening guidance
Frequently asked questions
I only have a screenshot of my dMMR result. What should I bring to genetic counselling?
Get the complete pathology report and original mismatch repair or MSI test report. Note the types of cancer and ages at diagnosis in your family. The clinician can decide whether more tests are needed.
Need help?
Tell us about your situation and needs. Incomplete records are welcome.